Duplantis is joined by Isaac Nader (1,500m), Jimmy Gressier (5,000/10,000m), Mattia Furlani (long jump), Pedro Pichardo (triple jump), Swedish compatriot Daniel Stahl (discus) and Leo Neugebauer (decathlon) in men's events.
Femke Broeders-Bol (400m hurdles but contesting the 800m), Ditaji Kambundji (100m hurdles) and Maria Perez (20km and 35km race walk but contesting the half marathon race walk) are the female world champions taking part.
Duplantis is also Olympic champion, alongside Jakob Ingebrigtsen (5,000m), Miltiadis Tentoglou (long jump), Keely Hodgkinson (800m), Yaroslava Mahuchikh (high jump) and Yemisi Mabry (shot put).
Duplantis, Ingebrigtsen, Tentoglou and Norway's 400m hurdler Karsten Warholm are all targeting their fourth successive European titles. Mahuchikh and Hodgkinson are eyeing a hat-trick of golds.
"Mondo" makes his return to competition after a scare that saw him withdraw from the London Diamond League meet with a left thigh problem after clearing 5.95 metres.
"No sign of injury after a professional examination that also included an MRI and x-ray," his agent Daniel Wessfeldt told AFP, adding: "His planned competition programme stays firm. Next meet the European championships in Birmingham."
The double Olympic and triple world champion has broken the world record 15 times, first with 6.17m back in 2020. His most recent mark was 6.31m in Sweden in March.
The championships, the first Europeans to be held in Britain, will also feature a host of home hopes, notably Olympic 800m champion Keely Hodgkinson, her training partner Georgia Hunter Bell and 2022 world 1,500m champion Jake Wightman.
Their teammate Dina Asher-Smith, the two-time 100m champion, could overtake the seven golds of Croatian discus thrower Sandra Elkasevic with another blue riband victory, to become the most successful athlete in the history of the championships.
In all, athletes from 49 nations will compete for 50 gold medals, including a mixed 4x100m relay for the first time. The 10 leading performances of the August 10-16 champs will each also be rewarded with a cheque for 50,000 euros.