Werner sustained the injury in his side's Champions League victory against Shakhtar Donetsk on Wednesday.

"Scans today in Leipzig showed that he has unfortunately torn the syndesmosis ligament in his left ankle and will therefore be out for the rest of 2022," Leipzig said in a statement.

Germany manager Hansi Flick was quick to express his disappointmnet about the news.  "It's very sad news. I feel really sorry for Timo that he will miss a World Cup that he was determined to play at," he said.

"Above all though, his absence is a big loss for the team. We all wish him a speedy recovery!"

Werner, who has 24 goals in 55 appearances for the national team, was part of the Germany squad at the 2018 World Cup and Euro 2020.