Bristol's Matias Moroni replaces Saracens' Lucio Cinti at outside centre while Mayco Vivas takes Boris Wenger's spot at tight-head prop for Saturday's game.
Cinti and Wenger drop to the bench for a repeat of Wednesday's heated football World Cup semi-final between the two countries, won by Lionel Messi's Argentina.
Elsewhere, among the replacements recently-crowned French Top 14 champion in Toulouse lock Efrain Elias, Leicester Tigers back-rower Joaquin Moro and prop Pedro Delgado are the other new faces from last Saturday's convincing win over Wales.
Argentina team to face England:
Starters: 15-Santiago Carreras; 14-Bautista Delguy, 13-Matias Moroni, 12-Justo Piccardo, 11-Mateo Carreras; 10-Tomas Albornoz, 9-Gonzalo Garcia; 8-Joaquin Oviedo, 7-Marcos Kremer, 6-Santiago Grondona; 5-Matias Alemanno, 4-Guido Petti; 3-Tomas Rapetti, 2-Julian Montoya (capt), 1-Mayco Vivas
Replacements: 16-Ignacio Ruiz, 17-Boris Wenger, 18-Pedro Delgado, 19-Efrain Elias, 20-Pablo Matera, 21-Joaquin Moro, 22-Simon Benitez Cruz, 23-Lucio Cinti