Kai Havertz and Martin Odegaard, however, might return for the Gunners, according to manager Mikel Arteta.
Manchester City will be without Jeremy Doku for their clash with Newcastle United, who themselves face Pep Guardiola's men without the talismanic Bruno Guimaraes.
Meanwhile, Liverpool's Arne Slot has a serious shortage of options at right-back, following Wataru Endo's recent injury, compounding Jeremie Frimpong and Conor Bradley's setbacks.
See who's missing and doubtful ahead of the next round of Premier League fixtures:
Aston Villa v Leeds (Saturday, 16:00 CET)
WON'T PLAY
Bizot M. | Red Card
Kamara B. | Knee Injury
McGinn J. | Knee Injury
Tielemans Y. | Ankle Injury
Okafor N. | Injury
DOUBTFUL
Alysson | Knock
Garcia A. | Muscle Injury
Brentford v Brighton (Saturday, 16:00 CET)
WON'T PLAY
Carvalho F. | Knee Injury
Milambo A. | Knee Injury
Ayari Y. | Shoulder Injury
Tzimas S. | Knee Injury
Webster A. | Knee Injury
DOUBTFUL
March S. | Knee Injury
Chelsea v Burnley (Saturday, 16:00 CET)
WON'T PLAY
Colwill L. | Knee Injury
Cucurella M. | Muscle Injury
Essugo D. | Injury
Gittens J. | Muscle Injury
Mudryk M. | Suspended
Amdouni Z. | Knee Injury
Beyer J. | Thigh Injury
Broja A. | Injury
Cullen J. | Knee Injury
Roberts C. | Groin Injury
Tresor M. | Ankle Injury
Tuanzebe A. | Achilles Tendon Injury
DOUBTFUL
Jorgensen F. | Injury
West Ham v Bournemouth (Saturday, 18:30 CET)
WON'T PLAY
Fabianski L. | Back Injury
Pablo | Calf Injury
Potts F. | Red Card
Doak B. | Hamstring Injury
Kluivert J. | Knee Injury
Soler J. | Injury
DOUBTFUL
Tavernier M. | Thigh Injury
Manchester City v Newcastle (Saturday, 21:00 CET)
WON'T PLAY
Doku J. | Calf Injury
Gvardiol J. | Broken Leg
Kovacic M. | Heel Injury
Bruno Guimaraes | Muscle Injury
Krafth E. | Knee Injury
Livramento V. | Hamstring Injury
Miley L. | Knee Injury
Schar F. | Ankle Injury
Wissa Y. | Knock
DOUBTFUL
Alleyne M. | Knock
Savinho | Health problems
Crystal Palace v Wolves (Sunday, 15:00 CET)
WON'T PLAY
Doucoure C. | Knee Injury
Lerma J. | Muscle Injury
Mateta J. | Knee Injury
Nketiah E. | Thigh Injury
Chiwome L. | Lacking Match Fitness
DOUBTFUL
Lacroix M. | Muscle Injury
Gomes A. | Injury
Hwang Hee-Chan | Injury
Toti | Hamstring Injury
Nottingham Forest v Liverpool (Sunday, 15:00 CET)
WON'T PLAY
Boly W. | Knee Injury
John Victor | Knee Injury
Sels M. | Groin Injury
Wood Ch. | Knee Injury
Bajcetic S. | Hamstring Injury
Bradley C. | Knee Injury
Endo W. | Injury
Frimpong J. | Injury
Isak A. | Broken Leg
Leoni G. | Knee Injury
DOUBTFUL
Savona N. | Knee Injury
Sunderland v Fulham (Sunday, 15:00 CET)
WON'T PLAY
Traore B. | Knee Injury
Reinildo | Knee injury
Lukic S. | Injury
DOUBTFUL
Alderete O. | Injury
Cairney T. | Calf Injury
Tottenham v Arsenal (Sunday, 17:30 CET)
WON'T PLAY
Bentancur R. | Muscle Injury
Bergvall L. | Ankle Injury
Danso K. | Toe Injury
Davies B. | Ankle Injury
Kudus M. | Muscle Injury
Kulusevski D. | Knee Injury
Maddison J. | Knee Injury
Odobert W. | Knee Injury
Romero C. | Red Card
Udogie D. | Muscle Injury
Merino M. | Leg Injury
DOUBTFUL
Porro P. | Muscle Injury
Richarlison | Hamstring Injury
Dowman M. | Ankle Injury
Havertz K. | Muscle Injury
Odegaard M. | Knock
Trossard L. | Injury
Everton v Manchester United (Monday, 21:00 CET)
WON'T PLAY
Grealish J. | Foot Injury
O'Brien J. | Red Card
Dorgu P. | Hamstring Injury
DOUBTFUL
Mount M. | Injury