Yasin Ayari started and finished the scoring, and substitute Mattias Svanberg also found the net, but it was Isak and Gyokeres who posed the main threat to Tunisia throughout the match.
Both players scored a goal and created a host of other chances as the Swedes cruised to the Group F win.
"Individually, of course, they are top players but I think together they can be a real threat," Potter told a press conference. "I think they’ll get better and better the more they play; they complement each other very well.
"I’m really pleased with the players," he added. "We know the quality of the individuals in the front positions but they needed a team to function.
"We weren’t perfect; we knew we wouldn’t be. But at the start of the game I thought we had good control."
Sunday's match was the first time Sweden and Tunisia have met in the World Cup.
Tunisia had not conceded a single goal in qualifying but Sunday marked the second straight game they had conceded five after losing 5-0 to Belgium in a warm-up match ahead of the tournament.
Sweden lead the group with three points after the Netherlands and Japan tied 2-2 earlier in the day. Sweden's next game is against the Netherlands on June 20 in Houston.
"We know we’ll meet a top team next and we have to be ready for that," said Potter.
The 2026 World Cup will be held from June 11th to July 19th in the United States, Canada and Mexico. The tournament will feature 48 national teams and will be played in 16 modern stadiums.
Match schedule and times | Group tables | Full squads for World Cup | How to watch the World Cup