Goransson had already suffered a first round loss alongside Evan King in the Men's Doubles - a three-set defeat to Petr Nouza and Neil Oberleitner - meaning his time in SW19 comes to an end on the middle weekend.
It's the second time the former Wimbledon Men's Doubles quarter-finalist has come unstuck in the opening round of the Mixed event, as he and New Zealander Routliffe were unable to put together similar form that saw them reach the last eight of the French Open a month ago.
The match began brightly for the pair, who forced a break of serve in the second game, but successive losses of serve in games seven and nine handed the first set to Harrison and Zhang.
The seventh game of the second set saw the Sweden-New Zealand pair under pressure again, saving three break points, but that pressure finally got to them in game nine, as the American and Chinese duo secured the break they needed before serving for the match in the next game.