Paul Goldschmidt, Cody Bellinger and Aaron Judge each snacked a homer off the first offering they saw from Milwaukee pitcher Nestor Corales, a former Yankee left-hander.
Austin Wells added a two-out homer to give the 27-time World Series champion Yankees their first four-homer inning since the club first took the field in 1903.
Goldschmidt, Bellinger and Judge also became the first Yankees to ever blast back-to-back-to-back homers to lead off a game.
Judge added a grand slam homer off Brewers' relief pitcher Connor Thomas in the third inning and smashed a two-run homer in the fourth inning as the Yankees seized an 18-6 lead through six innings.
The homers were the first with the Yankees for first baseman Goldschmidt, a former Arizona standout who played from 2019/24 with St. Louis, and outfielder Bellinger, a former Los Angeles Dodger who was traded by the Chicago Cubs to the Yankees last December.
Cortes, a Cuban-born American, was traded by the Yankees to Milwaukee last December for pitcher Devin Williams.
The Yankees went on to win 20-9, hitting nine homers and falling one short of the record for a game (10).