In what was the biggest story of the night, James became the first player in NBA history to score 50,000 career points, extending his lead as the league's all-time record scorer.
He gathered a pass from Luka Doncic and unfurled a sublime 25-foot three-pointer to move to 50,002 points in a clash with the New Orleans Pelicans that his Los Angeles Lakers side ultimately won 136-115.
Jimmy Butler and Brandin Podziemski gave Curry scoring support with 19 points apiece to give the Warriors a win which lifts them into sixth place in the Western Conference standings.
The Warriors have now won nine out of 10 games with Butler in the starting line-up since his trade from the Miami Heat.
"Y'all know who he is, and what he's been able to do in this league," Curry said. "He's a superstar. He's won and lifted teams and he's doing it with us. We're all trying to do our part around him."
The Eastern Conference-leading Cleveland Cavaliers romped to their 11th straight victory with a 139-117 blowout of the Chicago Bulls.
Donovan Mitchell led the Cavs scoring with 28 points as Cleveland improved to 51-10 for the season, leaving them eight games clear of second-placed Boston at the top of the East.
In Atlanta, Giannis Antetokounmpo scored 26 points to lead the Milwaukee Bucks past the Hawks with a 127-121 victory.
The Bucks are now fourth in the Eastern Conference with a 35-25 record.