The Atletico Madrid player, France's fourth-highest scorer with 44 goals in 127 appearances, will be replaced by midfielder Matteo Guendouzi following his withdrawal from the 23-man squad.
Guendouzi plays for Serie A club Lazio, on loan from Olympique de Marseille, and has been capped seven times for France.
France host Germany at Parc Olympique Lyonnais on Saturday, followed by Chile at Stade Velodrome on March 26th.